Going against the Grain
نویسنده
چکیده
2748 The data that would change the course of Jonathan Tilly’s career and cause an uproar in the field of ovarian biology almost never saw the light of day. In Tilly’s cell death lab, postdoctoral fellow Tomoko Kaneko had twice repeated her experiments to kill off mouse egg cells, but something was wrong because the egg cell numbers were still high after treatment with a chemotherapy drug. Kaneko consulted another postdoc in the lab, Josh Johnson, and together they tried to determine if she had made a technical mistake or perhaps switched her control and experimental groups. “All of us ‘knew’ that egg regeneration couldn’t be occurring,” says Johnson, referring to the long-held view that adult female mammals are born with a fixed pool of oocytes, or egg cells, which gradually declines in number with age. The work appeared to be an anomaly, but Johnson prodded Kaneko to take it to their advisor’s office. That 2002 meeting was the birth of an ongoing controversy that has shaken up the field of reproductive biology, with Tilly’s laboratory publishing data they interpret as evidence of egg regeneration occurring in adult mice.
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عنوان ژورنال:
- PLoS Biology
دوره 5 شماره
صفحات -
تاریخ انتشار 2007